Monthly Archives: February 2017

No Money in antibiotics

Corp-Pharmaceuticals are waiting until the epidemics are eminent before they even consider wasting research and production on antibiotics. This is not across the board of course, but the trend is there. Actually ‘saving’ the world is a low priority for corporations. making money once it gets really bad — well, that’s a profitable mode of operation.

Corp-Pharma = Evil.

“Antibiotic resistance is growing, and we are fast running out of treatment options. If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time.”

WHO priority pathogens list for R&D of new antibiotics

Priority 1: CRITICAL

  • Acinetobacter baumannii, carbapenem-resistant
  • Pseudomonas aeruginosa, carbapenem-resistant
  • Enterobacteriaceae, carbapenem-resistant, ESBL-producing

Priority 2: HIGH

  • Enterococcus faecium, vancomycin-resistant
  • Staphylococcus aureus, methicillin-resistant, vancomycin-intermediate and resistant
  • Helicobacter pylori, clarithromycin-resistant
  • Campylobacter spp., fluoroquinolone-resistant
  • Salmonellae, fluoroquinolone-resistant
  • Neisseria gonorrhoeae, cephalosporin-resistant, fluoroquinolone-resistant

Priority 3: MEDIUM

  • Streptococcus pneumoniae, penicillin-non-susceptible
  • Haemophilus influenzae, ampicillin-resistant
  • Shigella spp., fluoroquinolone-resistant

 

http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/

~~~

How to cure this? (ha!)

Put a society funded (government) bounty on creating effective drugs that combat drug resistant bacteria — with a guaranteed production and delivery of N numbers of doses over X number of years, all at an agreed upon ‘society benefiting’ fixed price.

Penalize drug companies that do not participate by adding additional months of FDA approval time to any drugs on the docket.

“Hey, Drug Companies! Society needs this. You’re in the business. DO IT! Or find another means to fill your shareholder’s bank accounts.”

 

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Complexic

We live in a world of opposites, black and white, up and down, in and out, over and under, but with an infinite array of variations between. Grey, the blending of black and white on a continuum of scale, is the perfect example. Things are rarely black or white, but grey.

What about simple vs complex? Is everything a mixture of the two? Something is rarely only simple just as it might be singularly complex. Or more accurately, something simple to you might be complex to me.

There’s a word we hear often which many people use incorrectly: simplistic. Often when people call something or some process ‘simplistic’ what they are generally applying is that they think the subject is simple — to them. Simplistic is much more insidious. Its origins are strange, having to do with plants, but today, simplistic generally means that you’ve assigned a theory or answer that OVER simplifies the solution; so much so that that your solution is now wrong, or at least incorrect on certain levels.

I think of simplistic as ‘simplifying to the point of error.”

Today, as I thought on this for no other reason than my mind does such things at times, I thought that everyone’s interpretation of the world — everything in the world — contained a degree of simplistic reasoning. To make our way in the world we must assume much. It’s just the way it is. We assume carrots are good to eat and most people’s assumptions about that would be simplistic. When we think we know something we undoubtedly only know some of it, rarely if ever *all* of it.  At some point our understanding of a thing will drift into the simplistic realm.

As I contemplated this I imagined the opposite of this. If a thing had so much white in it and so much black then it was grey. If we think of white as simplistic treatment, what would be the black side? I went searching. Nothing came up. So I dreamed up a new word: Complexic.

If simplistic meant simplified to the point of error then complexic might mean complex to the point of perfect understanding.

If the world if full of opposites, simple to complex, and our understandings of the world fall on a continuation between those two, at some point our knowledge or beliefs shift from simplistic to simple to complex to complexic. That is:

  • Our understanding is primitive to the point of being wrong.
  • Our understanding is simple but not wrongly so.
  • Our understanding is thorough, absorbing the complexity of a subject to where we generally understand it quite fully.
  • Our understanding is so complete that, for this topic, we’ve reached what we might call a topical nirvana, masters of the subject.

Do you have a complexic understanding of something or some process in the world?


The four act Bond

How to write a thrilling story.

A typical Bond 007 style sequence:

(jeopardy + conflict + risk = penalty/reward) +
(jeopardy + conflict + risk = reward) +
(jeopardy + conflict + risk = penalty) +
big jeopardy + big conflict + big risk = final reward

Some family, data or city is in jeopardy.
Bond arrives and conflict ensues.
At a crux in the conflict Bond makes a rash decision:
He partially succeeds but must pay an unexpected price. (Bond is fallible.)

Some greater entity is at risk.
Bond, known to the villain, cat and mouses in conflict.
Bond, attempting to redeem his initial failure, takes a greater risk:
He succeeds to acclaim. (Bond is arrogant.)

Bond is now in jeopardy along with a state or country or system.
Villain escalates conflict with Bond and the system.
Bond risks yet again, with hubris from prior success:
He fails, loses almost all, humiliated. (Bond is humble.)

World is in peril now.
Bond fights not only villain but the system too.
Bond risks all in last ditch attempt to beat villain and justify prior actions:
He succeeds, world is saved, Bond is hero, villains beware. (Bond is resilient.)


I’ve done everything I can

What happens when “you’ve done everything you can”?

As of this writing, every one of the abhorrent people Donald Drumpf has selected for his cabinet have been confirmed. Despite millions of dollars of time spent by Democrats to stymie the appointments — every one of them went through. And no doubt the remainder will proceed apace.

The Democrats in the Senate should have gone on vacation; gone to Rio or Bermuda or to party in Sydney. The result would have been the same. They knew going in they had a rat’s chance in a tent full of terriers of blocking any of the nominations. The only saving grace is the judicial branch finally standing up and going “Uh, I think we have a say in some of these ExecOrds that the Drumpf is tossing out like paper airplanes.”

And that’s at the top, the Senate. The epitome of our governing body.

What can WE possibly do down here? Protest? Whine in the streets?

Some will say the Democrats in the Senate put forth a solid effort. That all the protests — against the egregious ExecOrds that spontaneously organized and the MSM covered — had impact.

Bullshit!

Not a god-damned-thing-changed because *Democrats or protestors*.

It’s abundantly clear what we have to do. The people in the Blue States have to infect the people in the Red States with enlightenment. Our ONLY recourse is to change the governing representatives at the CITY, COUNTY, STATE and FEDERAL levels. But not in our /already/ blue states! We have to change the governments and representatives in the BLEEDING RED STATES!

Whining in the streets in Seattle, SF, Portland or New York won’t do a fricking thing. We need to change the backwards, countryfied, ultra-religious, Luddites  who live in the RED states! We need to reach out and infiltrate and infect the Righteous Right with the Rational Left. Iowa, Kansas, Missouri, Indiana, Kentucky, Carolinas, and all the rest all need to realize the BIG-ASS MISTAKE they made by believing in the Orange Buffoon.

No shit inequality is stifling the country. No shit corporations are gouging the populace and controlling government. No shit that the economy benefits only the top 10% of society. No shit that corporate provided healthcare costs way too much. No shit that the financial industry doesn’t give two fucks about you or me or anyone with an income less that $100k. No shit that labor has been hobbled by the myths that a free market will provide for all. No shit that the military is an enormous drain on the US budget. No shit that the country’s infrastructure needs hundreds of billions of support (that could come from repatriation of foreign corporate profits).

It’s a shit world but the only way to change things is to change our government representatives. And the only way to do that is to get the RED states to see the light (and not the orange tinged dark that Drumpf sold them).


Back to Dystopia

http://www.whitenoise.city/articles/apocalyptic-london-wells-orwell
Lexi Mize
The author does a sweeping job of collecting dystopian references, but just one or two notes on /why/ humanity spends so much time and effort imagining the Apocalypse: 1) it’s easier to envision destruction than slow, methodical change. 2) we’d rather the world end with us than continue on without us (what will we miss?)

My personal favorite (not mentioned) is that the act (and art) of survival has been lost on us. Your book The Knowledge is a perfect example of this. Without the need to struggle to survive, we’re left to ponder the why of existence.

Let’s face it, surviving in the first world is not much of a challenge. In other lands, sure, the everyday acquisition of food, water, safety, shelter are struggles. They’re living in a dystopia — today. We facebook meanderers probably worry about other more mundane or trivial aspects of modern life. Worries that we know have no consequence.

Envisioning the End allows us to, for a time, picture and dream of a time when our every step, our every decision might result in tragedy or triumph. Being forced to live in such a precarious world would imbue an edge of excitement, stir our basic evolutionary skills at surviving, expose that frisson of living that our mundane lives fail to provide.

 


Nothing wrong with suicide

Why Suicide Keeps Rising for Middle-Aged Men

“Suicide rates in the U.S. continue to rise, and working-age adults – particularly men – make up the largest increase, according to the Centers for Disease Control and Prevention. Middle-aged men in the 45 to 60 range experienced a 43 percent increase in suicide deaths from 1997 to 2014, and the rise has been even sharper since 2005. Untreated mental illness, the Great Recession, work-related issues and men’s reluctance to reach out for help converge to put them at greater risk for taking their own lives. And because men are more likely than women to use a gun, their suicide attempts are more often fatal.”

Bullshit!

Does no one realize that this may be the inevitable evolution of humanity?

Let’s face it. The Universe IS ABSURD! The reason for its existence is utterly unfounded. And, ipso facto, if the Universe is pointless anything within it is, by association, also pointless. Now don’t give me your bullshit arguments about any contrived reasons for existence — they are, by definition, contrived. Dreamed up. Fabricated by an overly large brain of an aberration species that just happens to be humanity.

Humanity is an accident brought forth in a chaotic stew of happenstance, all bound within a system of physics and phantasm that is this spontaneous creation that is the Universe. And if you THINK you’ve got a purpose, well, you undoubtedly dreamed it up, created it for your own purposes (or rather for DNA’s purpose, unbeknownst to you) to convince yourselves that life is worth living. That thoughts of suicide are an illness. Bullshit!

Suicide is simply the realization that, yes, the Universe is without purpose — AND THERE’S NO WAY YOU CAN PHILOSOPHIZE YOUR WAY OUT OF THAT FACT.

So, middle age men (me) are killing themselves more often? NO SHIT! It’s called achieving a higher understanding of the realities of existence — of which there are none. It’s intelligence, the attainment of the ultimate transcendent frame of mind. Not an illness. The only fucking reason I’m still typing this shit is that I’m a fucking coward. I’m a fraud. And the thoughts that bubble forth between unpacking the pistol, loading it with shells, finding the right time and location to vanish from existence — choke my resolve.


Super Halftime Show Bowl

What about a whole event/venue of nothing but halftime shows?

It’s not that I dislike football so much as I utterly despise it. In fact, all organized games that result in mega-million paychecks for anybody playing in a game smacks, to me, of Colosseum gladiators and barbarian behaviors that humanity is reticent to abandon. I don’t care how refined the skills of these players become — whether the game be played with a ball, a puck, or a birdie (they’re games NOT sports mind you), being paid to play a game simply points out how basic and frivolous humans actually are.

Note, the skills of such people are often worthy of accolades and acknowledgement, the skills; but NOT the money. This is corporatism at one of its ugliest moments, creating elitists from honest attention to one’s craft, corrupting any and all who subscribe to the practice.

So, yeah, I detest corporate team games — the Super Bowl being the most distasteful.

However, the halftime shows, now those appear to be different creatures entirely. They require the teamwork of hundreds if not thousands, many who volunteer. They show true art and choreography. They elevate artists displaying tasteful amalgams of songs and technical contrivances that astound.

Halftime shows are entertaining.

So, screw football. Assemble five or seven popular music artists and hold a gala-halftime show. That would be way better than some lame, crude football game.